Frequent inquiries, misdiagnoses, uncomfortable and noticeable symptoms, an inability to see a dermatologist on short notice, are all reasons why as pharmacists, you are often found in situations where patients ask you to solve a certain dermatologic problem. The most common choice then are safe and clinically tested products for neutral skincare. Melem is a natural protective cream with over 35 years of tradition. The active ingredients of lanolin, castor oil, and beeswax make this cream an ideal choice in skin protection, as well as the first choice when advising patients on dermatological problems. Its quality is further confirmed by the fact that its use has been clinically tested; it has earned ISO 9001 and 14001 certificates, and received numerous awards from the profession and from society.
- Awarded Gold Medal at the World Innovation Exhibition, Inpex 1999, Pittsburgh, U.S.A.
- The Croatian Chamber of Commerce’s recognition of high standards of quality, Croatian Quality, 16 February 1999
- The Croatian Chamber of Commerce’s recognition of high standards of quality, Originally Croatian, 27 January 2001
- Croatian Superbrand award 2006
- FDA approval for U.S. sales
|STORAGE:||At room temperature|
|EXPIRY DATE:||24 months (Melem 50 ml), 36 months (Melem in a stick), 60 months (Melem 10 ml and 35 ml)|
|DOES NOT CONTAIN:||Preservatives, dyes, allergens, silicones, aggressive medicines|
Why is Melem so unique?
Melem is a protective cream that contains natural protective ingredients of which lanolin, castor oil and beeswax are the most well-known.
Melem works on symptoms of problematic and sensitive skin. People of all ages may use it on various parts of the body. Its role is to prevent and protect skin from various effects and conditions the skin may be exposed to, with a reliable hydrating and regenerating effect. Melem heals sensitive skin much quicker, and effectively acts in the reduction of skin ailments and redness.
Given its positive effects on sensitive skin, Melem has a wide range of uses. What differentiates Melem from the rest is the fact that it is so wide-ranging in its protective care of skin, but also when we are faced with pre-existing skin conditions.
Effects of Melem
The multiple and long-lasting effects of Melem significantly help the skin with preventative and therapeutic uses.
REGENERATING/RENEWING ACTION – With its active substances, Melem creates a protective layer on the skin’s surface and works to renew the damaged layer of skin. Skin is no longer taut, dry nor rough, but rather soft and supple.
HYDRATING ACTION – With its active substances, Melem penetrates the uppermost layer of the epidermis and forms a protective barrier that prevents the loss of moisture from deeper layers of skin. With proper hydration of the outer layer, skin receives the moisture it needs, improving the protective function of the surface skin layer.
SOOTHING EFFECT – With its active ingredients, Melem helps soothe skin that has been exposed to various harsh weather conditions (wind, cold, dry air…). It also eases photo-induced skin redness (redness due to sun exposure).
In 2005, Melem was tested at the world-renowned institute for the evaluation of cosmetic products, ISPE in Milan, with the goal of testing its soothing and renewing action on the skin.
The clinical test results confirmed:
- The speed of skin renewal when using Melem is faster in comparison with untreated skin.
- Melem actively soothed damaged skin caused by SLS (sodium lauryl sulphate), in comparison with untreated skin.
- Melem was proven effective in calming photo-induced skin redness in comparison to untreated skin.
The efficacy of Melem was tested in the maternity ward at Koper Hospital in Slovenia on new mothers, and its microbiological sterility, efficacy, and harmlessness for both mother and child was proven.
The study took place from 01.02.-23.03.1994, on women who gave birth during that time. The aim of the study was to establish the beneficial use of Melem on parturient women for the prevention of cracked nipples during breastfeeding.
The results of the preventive use of Melem show very good success with:
- Patients (nursing is no longer painful, child does not refuse to nurse, no fear of pain…)
- Doctors (fewer problems in healing skin sores, simple use of an efficient remedy, improved reputation of the birthing hospital…)
- And pediatricians (less refusal to nurse, both by baby and by mother, no unwanted infections in baby’s mouths – thrush, no other reactions to commonly used creams…)
RESULTS: Within the study group where Melem was used, the likelihood of occurrence of cracked nipples was reduced, breastfeeding was facilitated, post-partum recovery was less painful, less refusal to nurse on the part of mothers, no rejection of nursing on the part of the newborn due to the taste of the nipple, and no occurrence of allergic reaction.
A clinical check of the breasts three days after birth and on the day of discharge confirmed the benefit and harmlessness for mother and baby. It is recommended to apply Melem onto nipples repeatedly during the day without the need to rinse off because it is completely sterile and harmless for newborn babies.
Therapeutic effect of active ingredients
The active ingredients and emollient effects of Melem yield various results:
- Occlusion effect – enables in-depth treatment of active elements
- Cooling effect – stimulates circulation and renews and calms tired skin
- Absorption/drying out effect – rapid absorption of active ingredients; protection and prevention of drying out; that is, restoring moisture and softness of skin
- Effect on pH balance of skin – regulates pH balance of skin (acidity) which is important in treatment of inflammatory processes
- Effect on penetration of efficient elements – easy absorption (penetration) into skin, leading to quick reabsorption of efficient elements
- Effect on smoothness and suppleness of skin – maintains skin’s natural moisture and suppleness along with long-lasting smoothness
- Effect on lipid composition of skin – replenishes lost lipids, thus restoring the weakened protective function of the skin
Clinical use of Melem
Besides its wide range of uses in protective skincare, Melem has an exceptionally broad spectre of application for skin faced with pre-existing problems.
- Dry skin (xeroderma), ichthyosis, and keratinization disorder
- Chronic pressure sores (decubitus)
- Chronic photo-damaged skin
- As a part of the ‘’Step-down” and corticosteroid interval therapy
- Complementary treatment for retinoid therapy
- Thermal protection
- Mechanical protection (ultrasound, lithotripsy)
- Dermatitis therapy (diaper rash, atopic dermatitis, neurodermatitis)
- First-degree burns
- Diabetic foot and skin damage due to blood sugar control, as well as insulin therapy
- As a vehiculum for individual prescriptions
Preventive uses of Melem
Melem has a very broad spectre of preventive uses:
- Dry skin – renews skin functions, instantly relieves taut and dry skin, and prevents the further loss of moisture.
- Dry and calloused skin – decreases roughness of all types of dry, hard, and calloused skin, i.e. on feet and heels
- Dry and chapped skin – the protective benefits of Melem prevent the damaging effects of detergents, chemicals and water; prevent the formation of hangnails, and chapped and darkened elbow skin
- Skin redness – instantly soothes red skin caused by weather conditions and insect bites.
- Waxing and shaving – instantly soothes red and irritated skin, while the treated skin recovers quicker and becomes soft and supple.
- Stretch marks – prevents the appearance of stretch marks on the thighs and stomach because Melem nourishes, renews, and improves skin structure and renews its softness and elasticity.
- Expressing breast milk and massage of breasts – with its easy application, Melem facilitates expression of breast milk and the massage of breasts
- Breastfeeding – excellent for breast-care while nursing and prevents cracking of nipples
- After-sun care – soothes taut skin after overexposure to sun
- Reactions to jewelry – helps to reduce skin sensitivity to metal and costume jewelry
- Babies and children – an ideal cream for the nourishment of children’s skin because it protects skin from moisture and prevents contact with harmful substances. Melem acts gently, soothes irritated skin in diaper rash, while intensively regenerating and nurturing baby’s gentle skin. Use Melem for soft and supple skin because it reliably protects from external influences (wind, cold, indoor heating), while at the same time acting to prevent further dehydration
The invention and manufacture of vaseline was patented in 1872 by Robert A. Chesebrough. His success stemmed from confidence in his product, which he first tested on cuts and burns on his own skin, demonstrating the effectiveness of vaseline on problematic and changed skin conditions.
Ever since its introduction into the United States pharmacopeia in 1880, there have been widespread scientific studies on the effectiveness and beneficial properties that vaseline offers to your skin, in terms of nourishment or various forms of treatment. Cosmetic manufacturers noted the beneficial properties of vaseline in moisturizing the skin, and began using it in cosmetic skincare products.
Scientific literature is full of evidence confirming that vaseline is an effective emollient. In a study performed in 1978, Klingman confirms that vaseline is the best product for relieving symptoms of basic xerosis (very dry skin), because no other substance works both quickly and comprehensively on dry skin. Klingman claims that vaseline is an excellent emollient thanks to its physical and pharmacological properties. Applying even the smallest amount of vaseline contributes to the noticeable improvement of dry skin symptoms.
Lazer and Lazer (1991) confirm in their article the occlusive effect of vaseline on the stratum corneum. It works in such a way that it replenishes lost lipids and creates a physical barrier preventing the loss of moisture through the skin. In a scientific study, Friberg and Ma (1993) express how vaseline offers an excellent occlusive effect to the outermost layer of skin, protecting it from rapid loss of moisture, and acting as a unique barrier for the retention of moisture.
Draelos (1990) and Rieger (1991) demonstrate vaseline’s effectiveness in reducing transepidermal water loss (TEWL). Rieger claims that vaseline’s occlusive properties and capacity to moisturize are entirely in accordance with accepted dermatological practice, cosmetic formulations and OTC skin protection.
In his study on allergic contact dermatitis, Fisher et al. (1988) claim that vaseline is the best occlusive emollient and ideal moisturizer for those with problem skin, especially those with dermatitis problems seeking dermatological advice.
Ghadially et al. (1992) show that when the skin is damaged in such a way that its lipid barrier is depleted, vaseline penetrates through the uppermost layer of the epidermis and aids in the restoration of damaged tissue, with added hydrating effects. In their in-vitro study, Frömder and Lippold (1993) demonstrated that vaseline reduced transepidermal water loss (TEWL) much more significantly than other lipids that were tested after use on skin.
Lanolin is obtained through a process of refining fat from sheep’s wool. Lanolin has excellent hydrating and emollient properties on human skin, acting as a protective barrier for skin just as a sheep’s wool protects a sheep from various climatic conditions. Its capacity to hydrate skin is connected to its capacity to bind water molecules. The beneficial properties of lanolin have been well-known for centuries.
When applied, lanolin penetrates into the uppermost layer of skin (stratum corneum), retaining itself more in the top layers.
Power and Fox (1957) demonstrated lanolin’s semi-occlusive effect and ability to reduce transepidermal water loss (TEWL). Applying lanolin (5.0-6.25 mg/cm2, measuring a thickness of film of 54 to 68 μm) onto the inner surface of the arm below the elbow reduced transepidermal water loss by 32%. Spruits reports of a 20 to 30% reduction of TEWL with 50-μm of lanolin film.
Given the fact that lanolin renews the clinical appearance of xerosis, it can also accelerate the renewal of the normal barrier function of normal skin that is acutely imbalanced. Elias et al. (1999) demonstrated that lanolin accelerates the recovery of the epidermal barrier that was damaged due to acetone use. A significant reduction in transepidermal loss of water (TEWL) is evident while using products with a mere 3% of lanolin content, after just 45 min of use. Even after a time span of 4 hours, a significant decrease was still evident. This shows that lanolin has a rapid and direct impact in renewing the permeable membrane, without interfering with the extruding mechanism of lamellar bodies and lipid synthesis that are essential for continued recovery.
Paraffin oil takes on the role of barrier between skin and air. It acts as an occlusive agent preventing water, which naturally seeps out of our body, from emitting through the skin. In this way, the skin does not dry out, and premature aging is prevented. The opposite occurs: hydration of the skin is enabled. Paraffin oil as a component of skin creams, lotions, and moisturizers has been used for over 100 years, and has an established wide range of uses.
Castor oil is known since ancient times for its therapeutic properties. It was used over 3500 years ago in ancient Egypt for skin wounds, sores and burns, and to rub on and protect sensitive eyelid skin. The oil is obtained through a cold pressing process from the ricinus communis plant bean. This oil has unique properties because when it is dry it creates a protective film that prevents the drying out of skin and loss of natural moisture. For these reasons it is most often used in cosmetic products.
Use and dosage
Use and dosage
- Melem is applied in very small quantities and in a very thin layer. For example, to protect both hands, it is enough to take a rice grain-sized amount of the product. In such small quantities, Melem offers adequate effects and leaves a pleasant velvety touch to the skin.
- Heat the required amount of the product between the palms of your hands because Melem disperses best when it is at body temperature.
- If after two or three minutes after application you feel you have greasy hands – it means you have used too much Melem.
- For quick results use Melem 2-3 times daily or more often if needed.
- A single gram of Melem is enough for five applications on your hands.